منابع مشابه
Tubulin polyglutamylation stimulates spastin-mediated microtubule severing
Posttranslational glutamylation of tubulin is present on selected subsets of microtubules in cells. Although the modification is expected to contribute to the spatial and temporal organization of the cytoskeleton, hardly anything is known about its functional relevance. Here we demonstrate that glutamylation, and in particular the generation of long glutamate side chains, promotes the severing ...
متن کاملSPIRAL2 Determines Plant Microtubule Organization by Modulating Microtubule Severing
One of the defining characteristics of plant growth and morphology is the pivotal role of cell expansion. While the mechanical properties of the cell wall determine both the extent and direction of cell expansion, the cortical microtubule array plays a critical role in cell wall organization and, consequently, determining directional (anisotropic) cell expansion. The microtubule-severing enzyme...
متن کاملMicrotubule-severing enzymes at the cutting edge.
ATP-dependent severing of microtubules was first reported in Xenopus laevis egg extracts in 1991. Two years later this observation led to the purification of the first known microtubule-severing enzyme, katanin. Katanin homologs have now been identified throughout the animal kingdom and in plants. Moreover, members of two closely related enzyme subfamilies, spastin and fidgetin, have been found...
متن کاملRegulation of microtubule severing by katanin subunits during neuronal development.
Katanin, the microtubule-severing protein, consists of a subunit termed P60 that breaks the lattice of the microtubule and another subunit termed P80, the functions of which are not well understood. Data presented here show that the ratio of P60 to P80 varies markedly in different tissues, at different phases of development, and regionally within the neuron. P80 is more concentrated in the cell...
متن کاملMicrotubule length distributions in the presence of protein-induced severing.
Microtubules are highly regulated dynamic elements of the cytoskeleton of eukaryotic cells. One of the regulation mechanisms observed in living cells is the severing by the proteins katanin and spastin. We introduce a model for the dynamics of microtubules in the presence of randomly occurring severing events. Under the biologically motivated assumption that the newly created plus end undergoes...
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ژورنال
عنوان ژورنال: Cell Motility and the Cytoskeleton
سال: 1999
ISSN: 0886-1544,1097-0169
DOI: 10.1002/(sici)1097-0169(1999)43:1<1::aid-cm1>3.3.co;2-r